Saleh A Bakheet Selected Research

5-aminoisoquinolinone

2/2021	5-Aminoisoquinolinone, a PARP-1 Inhibitor, Ameliorates Immune Abnormalities through Upregulation of Anti-Inflammatory and Downregulation of Inflammatory Parameters in T Cells of BTBR Mouse Model of Autism.
1/2020	5-aminoisoquinolinone attenuates social behavior deficits and immune abnormalities in the BTBR T+ Itpr3tf/J mouse model for autism.
2/2015	The role of poly(ADP-ribose) polymerase-1 inhibitor in carrageenan-induced lung inflammation in mice.
8/2014	Poly(ADP-ribose) polymerase-1 inhibitor modulates T regulatory and IL-17 cells in the prevention of adjuvant induced arthritis in mice model.

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Saleh A Bakheet Research Topics

Disease

35	Autistic Disorder (Autism) 05/2022 - 12/2016
28	Inflammation (Inflammations) 09/2022 - 09/2013
10	Neoplasms (Cancer) 01/2019 - 01/2011
9	Arthritis (Polyarthritis) 03/2021 - 09/2013
8	Neuroinflammatory Diseases 01/2020 - 12/2016
6	Experimental Arthritis 03/2021 - 09/2013
6	Rheumatoid Arthritis 01/2020 - 06/2014
6	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2018 - 01/2005
5	Pneumonia (Pneumonitis) 09/2022 - 04/2014
5	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 06/2022 - 03/2014
4	Nervous System Diseases (Neurological Disorders) 01/2019 - 10/2017
4	Cardiotoxicity 11/2017 - 01/2012
4	Hypertension (High Blood Pressure) 01/2014 - 04/2013
3	Autism Spectrum Disorder 01/2022 - 06/2020
3	Acute Kidney Injury (Acute Renal Failure) 10/2021 - 12/2007
3	Wounds and Injuries (Trauma) 02/2021 - 04/2013
3	Psoriasis (Pustulosis Palmaris et Plantaris) 06/2020 - 01/2018
3	Chromosome Aberrations (Chromosome Abnormalities) 01/2020 - 01/2016
3	Carcinogenesis 01/2020 - 03/2009
3	Edema (Dropsy) 10/2016 - 06/2014
3	Pleurisy (Pleuritis) 04/2015 - 04/2014
3	Necrosis 07/2014 - 09/2013
2	Colitis 01/2020 - 03/2014
2	Leukemia 11/2017 - 09/2013
2	Cardiomyopathies (Cardiomyopathy) 01/2016 - 01/2012
2	Liver Neoplasms (Liver Cancer) 01/2015 - 03/2009
2	Hepatocellular Carcinoma (Hepatoma) 01/2015 - 04/2014
1	Demyelinating Diseases (Demyelinating Disease) 01/2022
1	Memory Disorders (Memory Loss) 01/2022

Drug/Important Bio-Agent (IBA)

19	CytokinesIBA 01/2022 - 04/2013
11	Transcription Factors (Transcription Factor)IBA 01/2022 - 04/2014
9	Interleukin-17 (Interleukin 17)IBA 10/2021 - 04/2014
9	AntioxidantsIBA 02/2021 - 11/2016
7	Proteins (Proteins, Gene)FDA Link 09/2022 - 01/2005
7	Chemokine ReceptorsIBA 01/2022 - 12/2016
6	DNA (Deoxyribonucleic Acid)IBA 01/2021 - 09/2013
5	EnzymesIBA 02/2021 - 04/2013
5	Adenosine A2A Receptor (Adenosine A2A Receptors)IBA 01/2018 - 01/2017
5	CarrageenanIBA 11/2015 - 04/2014
4	phthalic acid (phthalate)IBA 05/2022 - 12/2020
4	3-nitrotyrosineIBA 10/2021 - 01/2020
4	5-aminoisoquinolinoneIBA 02/2021 - 08/2014
4	Oxidants (Oxidizing Agents)IBA 02/2021 - 01/2019
4	GlucocorticoidsIBA 07/2020 - 09/2013
4	Tyrosine Kinase InhibitorsIBA 01/2020 - 01/2015
4	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 01/2020 - 10/2016
4	ResveratrolIBA 01/2018 - 04/2013
4	Messenger RNA (mRNA)IBA 01/2015 - 04/2013
4	AntipyreticsIBA 01/2014 - 04/2013
3	Interleukin-9 (Interleukin 9)IBA 03/2021 - 10/2017
3	sinapinic acidIBA 02/2021 - 11/2016
3	Diethylhexyl Phthalate (DEHP)IBA 02/2021 - 12/2020
3	NADPH Oxidases (NAD(P)H oxidase)IBA 02/2021 - 03/2017
3	N- (1- (3- (4- ethoxyphenyl)- 4- oxo- 3,4- dihydropyrido(2,3- d)pyrimidin- 2- yl)ethyl)- N- pyridin- 3- ylmethyl- 2- (4- trifluoromethoxyphenyl)acetamideIBA 07/2020 - 12/2019
3	ibrutinibIBA 06/2020 - 10/2019
3	Imiquimod (Aldara)FDA LinkGeneric 06/2020 - 01/2018
3	AG 127 (AG 126)IBA 01/2020 - 10/2016
3	TyrphostinsIBA 01/2020 - 10/2016
3	Dexrazoxane (Zinecard)FDA LinkGeneric 11/2017 - 01/2016
3	AnthracyclinesIBA 11/2017 - 01/2016
3	Histamine (Histamine Dihydrochloride)FDA Link 07/2015 - 06/2014
3	Carnitine (L-Carnitine)FDA LinkGeneric 01/2010 - 12/2007
2	Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)IBA 09/2022 - 04/2013
2	lead nitrateIBA 09/2022 - 09/2022
2	NF-kappa B (NF-kB)IBA 09/2022 - 08/2014
2	Pharmaceutical PreparationsIBA 01/2022 - 09/2013
2	Interleukin-10 (Interleukin 10)IBA 10/2021 - 02/2021
2	LipopolysaccharidesIBA 02/2021 - 01/2017
2	Therapeutic UsesIBA 02/2021 - 10/2019
2	Environmental Pollutants (Pollutants, Environmental)IBA 02/2021 - 01/2021
2	PlasticizersIBA 01/2021 - 12/2020
2	Phosphotransferases (Kinase)IBA 01/2021 - 10/2019
2	3-aminobenzamideIBA 12/2020 - 03/2014
2	Toll-Like Receptor 4IBA 07/2020 - 03/2017
2	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)IBA 07/2020 - 11/2015
2	Agammaglobulinaemia Tyrosine KinaseIBA 03/2020 - 10/2019
2	Peroxidase (Myeloperoxidase)IBA 04/2017 - 11/2016
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 04/2017 - 11/2016
2	Caspase 3 (Caspase-3)IBA 04/2017 - 11/2016
2	CatalaseIBA 04/2017 - 11/2016
2	IonomycinIBA 01/2017 - 01/2017
2	Collagen Type II (Type II Collagen)IBA 01/2017 - 06/2014
2	phorbol-12-myristateIBA 01/2017 - 01/2017
2	CollagenIBA 01/2017 - 06/2014
2	Gentamicins (Gentamicin)FDA LinkGeneric 11/2016 - 01/2010
2	naringinIBA 04/2015 - 02/2014
2	Poly (ADP-Ribose) Polymerase-1IBA 02/2015 - 08/2014
2	Diethylnitrosamine (N-Nitrosodiethylamine)IBA 01/2015 - 03/2009
2	4-methylhistamineIBA 07/2014 - 06/2014
2	proanthocyanidinIBA 04/2014 - 09/2013
2	ChemokinesIBA 04/2014 - 03/2014
1	AcidsIBA 06/2022
1	SB-332235IBA 01/2022
1	N- (3- propylcarbamoyloxirane- 2- carbonyl)- isoleucyl- prolineIBA 01/2022
1	UCB 35625IBA 01/2022
1	Cathepsin BIBA 01/2022
1	methylmercuric chlorideIBA 01/2022
1	CreatinineIBA 10/2021

Therapy/Procedure

6	Therapeutics 01/2022 - 12/2016
4	Traditional Medicine (Folk Remedies) 01/2014 - 04/2013